Interactions: Next steps in learning...

Last updated: Sunday, July 05, 2015

You probably have many questions about the role that cytochrome p450 enzymes play in drug metabolism. A review that may answer a number of these was published in Pharmacology & Therapeutics in 2013. This is a lengthy and complex scientific paper, not really a clinical one. But if you are prepared to browse through it, you will find answers to questions like: Which isoenzymes are most important for drug clearance? Does gender or age affect enzyme activity? etc

There are two potential patient outcomes of drug interactions that pharmacists are often asked about and you may like to read more about these:

1. Prolonged QT interval. Here are two example online reviews that you may find helpful: Australian Prescriber (2015) and Therapeutic Advances in Drug Safety (2012). These are quite technical papers so you may prefer to browse them, rather than reading right through. There is also a helpful Drug and Therapeutics Bulletin on the topic if you have access.

2. Serotonin syndrome. The journal American Family Physician (2010) has a helpful review article that may assist you.