On-call scenario 3: Sources

Last updated: Monday, July 11, 2016

Information sources that you might have thought about looking in, include:


The SPCs for clarithromycin and citalopram both contraindicate their use with other drugs that prolong the QT interval because of the additive risk. Therefore, according to the UK licence, the combination would be contraindicated. Clarithromycin may also increase the plasma levels of citalopram through a CYP3A4 mediated interaction and put the patient at a further increased risk of side effects.


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