Interactions: Next steps in learning...

Last updated: Monday, November 15, 2021

You may have more questions about the role that cytochrome p450 enzymes play in drug metabolism. Stockley’s Drug Interactions has a detailed section on drug metabolism interactions that covers this family of enzymes, as well as others such as P-glycoprotein; you can find this section under the ‘General considerations and mechanisms’ tab.

Pharmacists are often asked about two potential outcomes of drug interactions that a wide range of medicines can cause. You may like to read more about these:

1. Prolonged QT interval
Here are two journal reviews that you may find helpful: Australian Prescriber (2015) and Therapeutic Advances in Drug Safety (2012). These are quite technical papers so you may prefer to browse them, rather than reading right through. There is also a helpful Drug and Therapeutics Bulletin on the topic if you have access.

SPS has also produced guidance on drug-induced QT prolongation

2. Serotonin syndrome