After a renal transplant

Last updated: Friday, August 03, 2018

Once a kidney transplant has stabilised, these patients should ideally have a reasonably healthy GFR of greater than 40mL/min. Consequently, dose reduction of drugs that are renally-eliminated is not usually needed. However, graft function does tend to diminish with time, so it is imperative to check renal function.

A transplanted kidney is positioned lower in the pelvis than the patient's own kidneys (which are left in place)
 and attached to the common iliac artery and vein
Courtesy of http://kidney.niddk.nih.gov/kudiseases/pubs/transplant, Wikimedia Commons 
Many of the immunosuppressants taken post-transplant interact with a variety of drugs and you should always check for interactions. Common immunosuppressants used to prevent transplant rejection include:
CiclosporinTacrolimusMycophenolate
SirolimusAzathioprineSteroids
Bear in mind that transplant patients only have one kidney, and it may not have perfect function, so it is vital to avoid all medicines that may impair kidney function (e.g. NSAIDs).